The gel differs fundamentally from hyaluronic acid medical products since it triggers restoration of hyaline cartilage, synovium, tendons and ligaments due to extracellular matrix compounds essential for tissue repair and restoration.

SpheroGEL® acts as a stabilizer for hyaluronic acid and liquid-crystalline compounds by forming hydrogen bonds between them and collagen. It triggers tissue restoration through the extracellular matrix compounds which contain factors modulating proliferative activity.

Long-term resorption of SpheroGEL® is achieved by microparticles of the cross-linked collagen fraction present in its
heterogeneous composition as well as by observance of the set rheological characteristics. After the resorption is
completed, the positive effect keeps accumulating due to activation of cell ability to proliferate. The duration of the implant
biodegradation depends on the size of SpheroGEL® microparticles.

SpheroGEL®, being an alternative to PRP therapy, does not require drawing blood, which eliminates any risk of redundant
invasions as well as occupational blood exposures of healthcare workers and significantly reduces the procedure duration.

 SpheroGEL® is obtained from animal collagen tissue checked for dangerous prion infections using
immunofluorescence assay.
 Hydrolyzed collagen is a high-performance biostimulant; it has exceptionally low antigenicity, exceptionally weak
anaphylactogenic and toxic properties. When injected into the body, the hydrolysate undergoes resorption and
splits into simpler compounds, which take part in the biosynthesis that occurs at the cellular level and
stimulates reparative processes, including own collagen production. The end products of collagen degradation
are carbon dioxide and water.
 The maximum molecular mass of SpheroGEL® components does not exceed 3500 Da, thus eliminating any risk of
allergic reaction.
 Gamma irradiation is used for sterilization as the most reliable contemporary method.